a two-stage meta-analysis identifies several new loci for

Exome

Lead (Pb) is a ubiquitous toxic metal present in the environment that poses adverse health effects to humans Inter-individual variation in blood Pb levels is affected by various factors including genetic makeup However limited data are available on the association between genetic variation and blood Pb levels The purpose of this study was to identify the genetic markers associated with

Gabrielle Lockett

We identified ten new risk loci bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci) Notably the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis

Association Schemes: Designed Experiments Algebra and

Using elicited opinion we construct prior distributions to represent the biases in each study and perform a bias‐adjusted meta‐analysis Adjustment had the effect of shifting the combined estimate away from the null by approximately 10% and the variance of the combined estimate was almost tripled

A Two

A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease Download PDF Česk info A previous genome-wide association (GWA) meta-analysis of 12 386 PD cases and 21 026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci

D

Several aspects related to RRT are now well established but others remain controversial In this review we review the available RRT modalities covering technical and clinical aspects We discuss several controversial issues provide some practical recommendations and where possible suggest a research agenda for the future

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A previous genome-wide association (GWA) meta-analysis of 12 386 PD cases and 21 026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in

A two

A previous genome-wide association (GWA) meta-analysis of 12 386 PD cases and 21 026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan

Genetic loci Medical search

Meta-analysis of 74 046 individuals identifies 11 new susceptibility loci for Alzheimers disease1 Theses 11 loci bring the total susceptibility loci count to 20 of which MEF2C is one We focus on a 1 megabase region surrounding the MEF2C gene which contains 208 variants whose presence is associated with the expression of MEF2C in 17 008 Alzheimers disease cases and 37 154 controls

Human autoimmune diseases: a comprehensive update

Other loci that are shared by several autoimmune diseases include TNFRSF14 IL‐12RB2 pseudouridylate synthase 10 (PUS10) signal transducer and activator of transcription 4 (STAT4) cytotoxic T lymphocyte‐associated protein 4 (CTLA4) CD80 IL‐12B thymocyte selection associated (THEMIS) chemokine C‐C motif receptor 6 (CCR6) RNA‐binding motif protein 17 (RBM17) RAD51B

SwePub

We identify eight novel susceptibility loci for cIMT one independent association at the previously-identified PINX1 locus and one novel locus for carotid plaque Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci

Blood

Crohn's disease is a relapsing and remitting inflammatory disorder with a variable clinical course Although most patients present with an inflammatory phenotype (B1) approximately 20% of patients rapidly progress to complicated disease which includes stricturing (B2) within 5 years We analyzed DNA methylation patterns in blood samples of pediatric patients with Crohn's disease at

SwePub

We identify eight novel susceptibility loci for cIMT one independent association at the previously-identified PINX1 locus and one novel locus for carotid plaque Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci

Genetics of alcoholic liver disease and non

Alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver disease globally Both ARLD and NAFLD are multifactorial and refer to a spectrum of disease severity ranging from steatosis through steatohepatitis to fibrosis and cirrhosis Both diseases exhibit substantial inter-patient variation in long-term outcomes and are best

Nonsynonymous variants in MYH9 and ABCA4 are the most

In our study MYH9 is the most frequent risk loci in the Taiwanese population providing further evidence for the involvement of MYH9 in the etiology of nonsyndromic CL/P A recent GWAS of several populations revealed markers in/near the gene encoding ABCA4 indicating a

metaanalysis – Page 2 – ZarLab

Over the past several years Genome Wide Association Studies (GWAS) have discovered hundreds of genetic variants involved in complex diseases (10 1056/NEJMra0905980) The vast majority of these variants do not lie in the protein coding regions of genes and thus do not affect what the gene produces but instead likely affect how the genes are regulated

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A two-stage meta-analysis identifies several new loci for Parkinson's disease (PD) loci This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan However the second stage genotyping array the ImmunoChip included a larger set of 1 920 SNPs selected on

Exploring causality in the association between circulating

Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC) establishing causality has proven challenging Since vitamin D is modifiable these observations have substantial clinical and public health implications Indeed many health agencies already recommend supplemental vitamin D

Genetic perspective on the synergistic connection between

genes VPS13C and ATP10B and several APS genes en-code proteins involved in endo-lysosomal functions VPS13C The vacuolar protein sorting 13 C (VPS13C) gene was first identified as a new risk gene for PD in a meta-analysis of genome-wide association studies (GWAS) [230] and later homozygous and compound heterozy-

Association Schemes: Designed Experiments Algebra and

Using elicited opinion we construct prior distributions to represent the biases in each study and perform a bias‐adjusted meta‐analysis Adjustment had the effect of shifting the combined estimate away from the null by approximately 10% and the variance of the combined estimate was almost tripled

A Two

and STX1B/16p11 loci hence suggesting potential molecular mechanisms and candidate genes at these risk loci Citation: International Parkinson's Disease Genomics Consortium (IPDGC) Well come Trust Case Control Consortium 2 (WTCCC2) (2011) A Two-Stage Meta-Analys is Identifies Several New Loci for Parkinson's Disease

Biomarkers In Risk Assessment: Validity And Validation

Kriebel (1994) described a two-stage approach to derive estimates of dose from exposure data and then linked them to epidemiological models estimating disease risk Such an approach incorporates physiological processes into epidemiological modeling and

Psoriasis and Other Complex Trait Dermatoses: From Loci

Driven by advances in molecular genetic technologies and statistical analysis methodologies there have been huge strides TongWein in dissecting the complex genetic basis of many inflammatory dermatoses One example is psoriasis for which application of classical linkage analysis and genome-wide association investigation has identified genetic loci of major and minor effect

Emerging patterns of genetic overlap across autoimmune

Several recent reviews have summarized emerging work that identifies both genetic loci that are shared across the spectrum of autoimmune disease and the biologic pathways whose involvement is implicated by these shared loci [15 16 18 19] For example Zhernakova et al

Gabrielle Lockett

We identified ten new risk loci bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci) Notably the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis

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